Structure Based Drug Design

The structure based drug design service and consulting are based on our broad knowledge of protein structure and strong medicinal and synthetic chemistry background and deep understanding of drug discovery cycle. Rebexsess' internationally recognized expertise in Structure Based Drug Design/Rational Drug Design allows the integration of the computational methods into medicinal chemistry as custom research service. Through our service will help client achieve:

  • Raise funding for startup companies
  • Increase stock value for client companies
  • Add values to client companies

Structure based drug design service

Rebexsess provides following services:

  • Development of SAR in context of receptor
  • Use of structure to improve potency and selectivity
  • Use of structure to improve “Drug-like?properties
  • Computational docking of small molecules to protein of interest
  • Computational analysis of docked pose
  • Oversight of overall SBDD process
  • With Partners: Crystallograhy of New Ligands
  • With Partners: Synthesis of Small Molecules
  • With Partners: Biological Analysis of New Ligands
  • With Partners: Virtual Screening of Small Molecule Libraries
  • Consulting:
  • Guidance on the integration of the various disciplines in the context of generating clinical candidates
  • Extensive experience with proteases, protein kinases and nuclear hormone receptors
  • Expertise in peptidomimetic design
  • Coordination of a full cycle in structure based drug design from crystallography, protein biochemistry to computer-aid modeling